The Practice of Prophetic Imagination: Preaching an Emancipating Word

Title: The practice of prophetic imagination : preaching an emancipating word. Author: Walter Brueggemann. Publisher: Minneapolis : Fortress Press, ©2012. ISBN: 978080069897

Neuropharmacological targets for drug action in vestibular sensory pathways

The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that may act to enhance or inhibit the effect of the primary neurotransmitters [i.e., glutamate (Glu) and acetylcholine (ACh)] or alter their patterns of release. This review summarizes various efforts to identify drug targets including neurotransmitter and neuromodulator receptors in the vestibular sensory pathways. Identifying these receptor targets provides a strategic basis to use specific pharmacological tools to modify receptor function in the treatment and management of debilitating balance disorders. A review of the literature reveals that most investigations of the neuropharmacology of peripheral vestibular function have been performed using in vitro or ex vivo animal preparations rather than studying drug action on the normal intact vestibular system in situ. Such noninvasive approaches could aid the development of more accurate and effective intervention strategies for the treatment of dizziness and vertigo. The current review explores the major neuropharmacological targets for drug action in the vestibular system

A sum-product theorem in function fields

Let $A$ be a finite subset of \ffield, the field of Laurent series in $1/t$ over a finite field $\mathbb{F}_q$. We show that for any $\epsilon>0$ there exists a constant $C$ dependent only on $\epsilon$ and $q$ such that $\max\{|A+A|,|AA|\}\geq C |A|^{6/5-\epsilon}$. In particular such a result is obtained for the rational function field $\mathbb{F}_q(t)$. Identical results are also obtained for finite subsets of the $p$-adic field $\mathbb{Q}_p$ for any prime $p$.Comment: Simplification of argument and note that methods also work for the p-adic

Induced Gravity II: Grand Unification

As an illustration of a renormalizable, asymptotically-free model of induced gravity, we consider an $SO(10)$ gauge theory interacting with a real scalar multiplet in the adjoint representation. We show that dimensional transmutation can occur, spontaneously breaking $SO(10)$ to $SU(5){\otimes}U(1),$ while inducing the Planck mass and a positive cosmological constant, all proportional to the same scale $v$. All mass ratios are functions of the values of coupling constants at that scale. Below this scale (at which the Big Bang may occur), the model takes the usual form of Einstein-Hilbert gravity in de Sitter space plus calculable corrections. We show that there exist regions of parameter space in which the breaking results in a local minimum of the effective action, and a {\bf positive} dilaton $(\hbox{mass})^2$ from two-loop corrections associated with the conformal anomaly. Furthermore, unlike the singlet case we considered previously, some minima lie within the basin of attraction of the ultraviolet fixed point. Moreover, the asymptotic behavior of the coupling constants also lie within the range of convergence of the Euclidean path integral, so there is hope that there will be candidates for sensible vacua. Although open questions remain concerning unitarity of all such renormalizable models of gravity, it is not obvious that, in curved backgrounds such as those considered here, unitarity is violated. In any case, any violation that may remain will be suppressed by inverse powers of the reduced Planck mass.Comment: 44 pages, 5 figures, 2 tables. v2 has new discussion concerning stability of SSB plus related appendix. Additional references added. v3 is version to be published; contains minor revision

Improved bounds on the set A(A+1)

For a subset A of a field F, write A(A + 1) for the set {a(b + 1):a,b\in A}. We establish new estimates on the size of A(A+1) in the case where F is either a finite field of prime order, or the real line. In the finite field case we show that A(A+1) is of cardinality at least C|A|^{57/56-o(1)} for some absolute constant C, so long as |A| < p^{1/2}. In the real case we show that the cardinality is at least C|A|^{24/19-o(1)}. These improve on the previously best-known exponents of 106/105-o(1) and 5/4 respectively

Zero modes in de Sitter background

There are five well-known zero modes among the fluctuations of the metric of de~Sitter (dS) spacetime. For Euclidean signature, they can be associated with certain spherical harmonics on the $S^4$ sphere, viz., the vector representation $\bf5$ of the global $SO(5)$ isometry. They appear, for example, in the perturbative calculation of the on-shell effective action of dS space, as well as in models containing matter fields. These modes are shown to be associated with collective modes of $S^4$ corresponding to certain coherent fluctuations. When dS space is embedded in flat five dimensions $E^5,$ they may be seen as a legacy of translation of the center of the $S^4$ sphere. Rigid translations of the $S^4$-sphere on $E^5$ leave the classical action invariant but are unobservable displacements from the point of view of gravitational dynamics on $S^4.$ Thus, unlike similar moduli, the center of the sphere is not promoted to a dynamical degree of freedom. As a result, these zero modes do not signify the possibility of physically realizable fluctuations or flat directions for the metric of dS space. They are not associated with Killing vectors on $S^4$ but can be with certain non-isometric, conformal Killing forms that locally correspond to a rescaling of the volume element $dV_4.$ For convenience, we frame our discussion in the context of renormalizable gravity, but the conclusions apply equally to the corresponding zero modes in Einstein gravity. We expect that these zero modes will be present to all orders in perturbation theory. They will occur for Lorentzian signature as well, so long as the hyperboloid $H^4$ is locally stable, but there remain certain infrared issues that need to be clarified. We conjecture that they will appear in any gravitational theory having dS background as a locally stable solution of the effective action, regardless of whether additional matter is included.Comment: v4, 28pages, no figures; final journal form, minor changes in text and refs from v